助理总监 - 人类数据与计算生物学
Assoc. Director - Human Data & Computational Biology
### **职业类别**
研究
### **职位描述**
### 加入安进为患者服务的使命
在安进，如果你觉得自己是更大事业的一部分，那是因为你确实是。我们共同的使命——为患有严重疾病患者服务——推动着我们所做的每一件事。
自1980年以来，我们在对抗世界上最难治愈的疾病方面，帮助开创了生物技术的世界。我们专注于四个治疗领域——肿瘤学、炎症、普通医学和罕见病——每年影响数百万患者。安进正在推进广泛的药物管线，用于治疗癌症、心脏病、炎症性疾病、罕见病以及肥胖及其相关疾病。作为安进团队的一员，你将帮助对患者的生活产生持久的影响，因为我们研究、制造并提供创新药物，帮助人们过上更长、更充实、更幸福的生活。
我们获奖的文化具有协作性、创新性和以科学为基础。如果你热衷于挑战，并且能从其中的机会中找到动力，那么你将在安进团队中茁壮成长。加入我们，改变患者的生活，同时改变你的职业生涯。
**职位：高级主任 – 人类数据与计算生物学**
### **你将做什么**
让我们一起行动，改变世界。在这个关键角色中，你将帮助在罕见病研究团队中建立并领导人类数据与计算生物学能力。你将成为多个疾病领域的科学合作伙伴，整合人类基因组学、多组学、患者来源的数据和计算方法，以识别、优先排序和验证新的治疗机会。我们正在寻找一位兼具深厚计算专业知识和强大生物学直觉，并对理解疾病机制充满热情的科学家。
**主要职责**
- 开发和实施支持靶点发现、验证和优先排序的计算策略。
- 分析和解释大规模生物数据集，包括基因组、转录组、蛋白质组、影像和临床数据。
- 利用人类遗传证据来加强疾病理解和治疗假说的生成。
- 与内部和外部合作伙伴紧密合作，将人类基因组学整合到早期发现项目中。
- 建立可扩展的分析工作流程和方法，适用于多个疾病领域。
- 评估和实施新兴计算工具和技术。
查看英文原文
### **Career Category**
Research
### **Job Description**
### Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
**Position: Assoc. Director – Human Data & Computational Biology**
### **What you will do**
Let’s do this. Let’s change the world. In this vital role you will help establish and lead the Human Data & Computational Biology capability within the Rare Disease Research Team. You will serve as a scientific partner across multiple disease areas, integrating human genetics, multi-omics, patient-derived data, and computational approaches to identify, prioritize, and validate novel therapeutic opportunities. We are seeking a scientist who combines deep computational expertise with strong biological intuition and a passion for understanding disease mechanisms.
**Key Responsibilities**
- Develop and implement computational strategies that support target discovery, validation, and prioritization.
- Analyze and interpret large-scale biological datasets, including genomic, transcriptomic, proteomic, imaging, and clinical data.
- Leverage human genetic evidence to strengthen disease understanding and therapeutic hypothesis generation.
- Collaborate closely with internal and external partners to integrate human genetics into early-stage discovery programs.
- Establish scalable analytical workflows and approaches that can be applied across multiple disease areas.
- Evaluate and implement emerging computational and AI-enabled approaches that accelerate scientific insight generation.
- Identify opportunities to integrate new technologies and analytical methods into the Rare Disease Research operating model.
- Work closely with disease biology pods to frame biological questions and translate computational findings into actionable scientific insights.
- Contribute to scientific evaluations of external opportunities, collaborations, and business development activities.
- Present scientific findings and recommendations to project teams, governance forums, and leadership groups.
- Establish processes and frameworks that promote human-data-driven decision making.
- As the function grows, participate in recruiting, developing, and leading future computational biology team members.
**What we expect of you**
We are all different, yet we all use our unique contributions to serve patients. The professional we seek is an Associate Director with the following qualifications:
**Basic Qualifications**
- Doctorate degree and 3 years of experience applying computational approaches to biological and translational research questions
OR
- Master’s degree and 7 years of analytics experience applying computational approaches to biological and translational research questions
OR
- Bachelor’s degree and 9 years of analytics experience applying computational approaches to biological and translational research questions
OR
- Associate’s degree and 12 years of analytics experience applying computational approaches to biological and translational research questions
OR
- High school diploma / GED and 14 years of analytics experience applying computational approaches to biological and translational research questions
**Preferred Qualifications**
- Demonstrated expertise in human genetics, genomics, computational biology, or multi-omics analysis.
- Strong track record of applying computational approaches to understand disease biology and identify therapeutic opportunities.
- Ability to translate complex computational findings into clear biological insights and actionable scientific recommendations.
- Experience working across multiple disease areas and integrating diverse biological datasets to answer challenging scientific questions.
- Deep curiosity about disease mechanisms and a demonstrated passion for solving biological problems.
- Experience partnering closely with experimental scientists to drive discovery and target validation efforts.
- Experience leveraging human genetics to support target identification, validation, and prioritization.
- Familiarity with machine learning, AI-enabled discovery approaches, knowledge graphs, or advanced analytical methods is desirable.
- Demonstrated ability to influence scientific strategy within highly collaborative and matrixed organizations.
- Experience mentoring scientists and contributing to development of high-performing teams.
- Excellent communication skills and ability to engage effectively with scientists, leadership teams, and external collaborators.
- High learning agility, scientific curiosity, and comfort operating in rapidly evolving research environments.
- Passion for building new capabilities, embracing innovation, and advancing the future of data-driven rare disease discovery.
### **What you can expect of us**
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
### Apply now and make a lasting impact with the Amgen team.
### **careers.amgen.com**
.
**Salary Range**
186,278.35USD -252,023.65 USD