Senior Technical Product Manager

PAXAFE is a logistics orchestration & decision intelligence SaaS platform that helps Cold Chain planning, logistics and quality teams consolidate their transportation data agnostically, digitize and automate product quality and lane qualification decisions, and operationalize prescriptive recommendations in the transportation network.
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Acting as the cold chain trust layer whose mission is to drive towards zero transportation waste, PAXAFE works with cold chain manufactures and service providers to reduce product loss, improve operational efficiencies and make more informed decisions in real-time.
PAXAFE's vision is to become the backend intelligence infrastructure that powers every temperature, time and value-sensitive shipment in the world.
PAXAFE is backed by great VCs (Framework Venture Partners, Ubiquity Ventures, Venture53, RoseCliff Ventures, etc.) and CVCs (Microsoft M12, Northwestern Mutual, Greenlight Re)
The Role
As a Senior Technical Product Manager at PAXAFE, you will own and drive the development of PAXAFE's core product modules and AI-powered intelligence capabilities. You'll be responsible for evolving our 4 flagship modules — Lane Qualification, Data-Agnostic Visibility Command Center, Temperature Release, and Insights (Performance & Risk Monitoring) — while pioneering the integration of LLM and agentic workflows that transform how pharmaceutical supply chain teams interact with and act on supply chain intelligence.
Your primary customers will be pharmaceutical logistics teams, quality assurance managers, supply chain operations leaders, and cold chain specialists who rely on PAXAFE’s CONTXT platform to make critical decisions about temperature-sensitive shipments. You'll also work closely with PAXAFE's internal teams (Solutions Engineers, Data Scientists, ML Engineers, Customer Success) to ensure our AI capabilities deliver measurable value and seamless user experiences.
This is a strategic, high-ownership position that requires vision, leadership, and technical fluency. You will define product roadmaps, drive execution, and collaborate with design, engineering, and data science teams to deliver AI-native features that automate decisions, surface insights proactively, and enable natural language interaction with complex supply chain data. You'll be at the forefront of applying cutting-edge LLM and agentic AI technologies to solve real-world pharmaceutical logistics challenges.
Key Responsibilities
Product Module Ownership & Development

• Own the product strategy and roadmap for PAXAFE's 4 core modules: (1) Lane Qualification — carrier, packaging and route performance & risk evaluation and lane qualification workflows, (2) Data-Agnostic Visibility Command Center — operational dashboards and real-time shipment monitoring, (3) Temperature Release — intelligent temperature-release workflows and GxP compliance automation, (4) Insights — analytics & trend analysis, performance & risk monitoring

• Define and prioritize features that deliver measurable customer value, focusing on minimizing scope and maximizing impact for pharmaceutical supply chain operations

• Gather insights through direct customer engagement with pharmaceutical logistics teams, QA managers, and supply chain operations to understand workflows, pain points, and decision-making processes.

• Translate complex pharmaceutical logistics requirements (real-time visibility, GxP compliance, temperature excursions, carrier performance, lane qualification criteria) into intuitive product features that simplify rather than complicate user workflows.

• Collaborate with engineering teams to deliver scalable, technically feasible solutions that process diverse data from IoT providers (Sensitech, ELPRO, Controlant, Tive) and 3PL systems (UPS, FedEx, DHL, World Courier, Kuehne+Nagel).

• Balance the needs of multiple user personas across the 4 modules — operations teams monitoring shipments in real-time, QA teams making release decisions, analysts reviewing performance trends, and supply chain leaders qualifying new lanes.

LLM & Agentic Intelligence Integration

• Pioneer the integration of Large Language Models (LLMs) and agentic AI workflows across PAXAFE's product modules to enable natural language queries, automated insights, and autonomous decision-making.

• Design and ship AI-powered features such as: conversational interfaces for supply chain data ("Show me all shipments at risk in the Northeast corridor this week"), automated root cause analysis for temperature excursions, predictive recommendations for lane qualifications, intelligent alerting that surfaces the right information at the right time, and AI-generated performance summaries.

• Define agentic workflows that automate complex multi-step processes: autonomous temperature-release decisions based on contextualized data and compliance rules, proactive risk mitigation actions triggered by predictive models, automated compliance documentation generation, intelligent alert routing and escalation, and self-healing integration workflows.

• Partner with data science and ML teams to leverage PAXAFE's semantic data layer and ontology as the foundation for accurate, context-aware LLM responses and agent actions.

• Stay ahead of emerging trends in LLMs, agentic AI, RAG (Retrieval-Augmented Generation) architectures, prompt engineering, and their practical applications in enterprise B2B workflows.

• Define success metrics for AI feature adoption, accuracy, and business impact (e.g., time saved, decisions automated, errors prevented, manual processes eliminated).

• Ensure AI capabilities enhance rather than replace human judgment — designing systems that augment decision-making with transparency, explainability, and user control.

Cross-Functional Leadership & Execution

• Work closely with Solutions Engineers to understand implementation challenges and ensure product features reduce integration complexity and accelerate customer time-to-value.

• Collaborate with Design to create intuitive, consumer-grade user experiences for complex pharmaceutical supply chain workflows — making AI-powered insights accessible and actionable for users of varying technical backgrounds.

• Partner with Engineering to translate product requirements into scalable technical solutions, balancing innovation with delivery speed and system reliability.

• Coordinate with Data Science and ML teams to ensure model outputs are properly integrated into product experiences and that feedback loops improve model performance over time.

• Document product requirements, user stories, AI model behaviors, and integration patterns to enable consistency and scalability across customer deployments.

• Champion a customer-obsessed, data-first culture where AI enhances rather than replaces human judgment, and where complex problems are solved through thoughtful product design.

• Present product vision, roadmaps, and progress to customers, executives, and stakeholders, translating complex AI capabilities into clear business value and ROI.

• Comfortable speaking directly with operational leadership at pharmaceutical companies to shape solutions, gather feedback, and ensure product-market fit.

Who We're Looking For
Experience

• 5+ years in product management (or related technical role), with at least 2 years building AI/ML-powered B2B/SaaS products or data-intensive applications.

• Proven track record shipping highly successful and innovative products with your fingerprints all over them — and you're deeply proud of what you've accomplished. History of successfully launching and iterating on SaaS and/or B2B products.

• Strong technical fluency with AI/ML concepts, LLMs, agentic workflows, and their practical applications in enterprise software. You don't need to write production code, but you can hold your own in technical conversations with data scientists and ML engineers.

• Experience building products that leverage LLMs, conversational AI, or autonomous agent systems. You understand the capabilities and limitations of these technologies and know how to apply them to solve real business problems.

• Deep understanding of how to design AI-powered features that enhance user productivity and deliver measurable outcomes rather than creating "AI for AI's sake" — you focus on business value and user adoption.

• Prior experience collaborating with data science, ML engineering, software engineering, and design teams to ship products in a B2B/SaaS environment.

• Ability to establish credibility quickly with technical teams and business stakeholders. You gather, interpret, and prioritize feedback from quantitative data, qualitative user research, and direct customer engagement.

• Excellent communication skills — comfortable presenting to customers, executives, engineers, and internal stakeholders, translating complex AI capabilities into clear business value and user benefits.

• Vision & execution. You craft a coherent product vision, strategy and roadmap and have a "driver" personality to get things done.

• A great collaborator, biased toward action and an excellent simplifier - constantly pushing toward clarity and delivery.

• Passionate about building businesses, not features. Focused on minimizing scope and maximizing value for customers.

• Customer obsessed. You take on complex product challenges and simplify them to avoid making them our users' and partners' problems.

• Entrepreneurial experience building and leading products, including ownership and optimization of business performance metrics.

Bonus Qualifications

• Experience in pharmaceutical logistics, cold chain management, life sciences supply chain, or GxP-regulated environments.

• Familiarity with IoT device integration, telemetry processing, and real-time data streaming architectures.

• Knowledge of temperature-controlled logistics, thermal packaging, temperature excursion management, or pharmaceutical quality requirements (GDP, GMP compliance).

• Experience with iPaaS platforms (Prismatic preferred), Supabase, PostgreSQL, or similar data infrastructure.

• Hands-on experience with prompt engineering, RAG architectures, or building LLM-powered applications.

• Understanding of pharmaceutical compliance frameworks (GDP, GMP) and their impact on product requirements and workflows.

• Previous experience building analytics products, operational dashboards, real-time monitoring systems, or business intelligence tools.

• Background in enterprise SaaS products serving regulated industries (healthcare, pharma, finance, logistics).

What Success Looks Like
First 30 Days:

• Master PAXAFE's 4 product modules (Command Center, Automated Temp. Release, Insights, Lane Qualification), customer workflows, and core data flows across the CONTXT platform

• Complete customer and internal user interviews to deeply understand current pain points, feature requests, and AI/automation opportunities

• Identify quick wins for AI-powered enhancements that can deliver immediate value to customers

• Build strong relationships with Engineering, Data Science, Solutions, Design, and Customer Success teams

First 90 Days:

• Own and deliver at least one high-impact AI feature or module enhancement that demonstrates measurable customer value (e.g., time saved, errors reduced, decisions automated)

• Define success metrics for AI feature adoption, accuracy, and business impact across the 4 modules

• Create a comprehensive AI/LLM integration roadmap for the next 12 months with clear prioritization and customer-validated initiatives

• Establish yourself as the product thought leader on AI capabilities within PAXAFE

First 6 Months:

• Ship multiple AI-powered features across the 4 modules that demonstrably improve customer workflows, reduce manual effort, and enable faster decision-making

• Launch at least one agentic workflow that automates a multi-step process previously requiring human intervention (e.g., autonomous temperature-release decisions, intelligent alert routing)

• Establish PAXAFE as an AI innovation leader in pharmaceutical cold chain through customer presentations, case studies, webinars, or industry content

• Define and execute product roadmaps for all 4 modules with clear prioritization, customer-validated feature sets, and measurable success criteria

• Mentor product and cross-functional team members on AI product management and technical product leadership best practices

• Build deep relationships with key customers and gather insights that drive product strategy

Why You'll Love Working Here

• High-impact mission: Every project directly supports safe, compliant delivery of the world’s most important products worldwide (e.g. vaccines, life-saving therapies, food, etc.)

• PAXAFE has entered an exciting growth phase which provides for [and requires] a great deal of autonomy & leadership at every role & every level

• AI innovation playground: Work at the cutting edge of LLM and agentic AI applications in enterprise B2B software. Shape how pharmaceutical companies leverage AI to transform their supply chains. You'll be building AI products that solve real problems, not demos.

• Startup ownership: Join a cohesive, collaborative team where your ideas shape the future of our platform

• Remote-first flexibility: Work from anywhere (Central / Eastern US preferred)

• Cutting-edge tech stack: Work with the latest AI/ML technologies alongside modern infrastructure. Technologies include: LLMs & Agentic AI | Azure | Python | Prismatic | Supabase | PostgreSQL | LavinMQ | Inngest | IoT | shadcn | Linear | Figma.

• Growth opportunity: Step into a foundational technical leadership role with direct visibility to PAXAFE's executive team and Fortune 500 pharmaceutical customers. Shape the product direction at a high-growth startup.

• Comprehensive benefits: Competitive base salary, equity participation, five weeks PTO, and full healthcare coverage

Our Core Values

• Create Magic: Deliver products that exceed customer expectations and solve real problems elegantly

• Own With Pride: Take ownership of outcomes and deliver with excellence

• Navigate With Intent: Make strategic decisions with clarity and purpose

• Think Deep, Act Fast: Balance thorough analysis with rapid execution

• Enjoy the Journey: Celebrate wins and maintain perspective

• X-hibit Teamwork: Collaborate across functions and support each other's success

• Tackle With Empathy: Understand customer and team needs deeply before proposing solutions

Ready to build the future of AI-powered pharmaceutical supply chain intelligence?
If you're ready to join a company that's pioneering LLM and agentic AI applications in pharmaceutical cold chain logistics — creating products that save lives while pushing the boundaries of what's possible with AI — then we want to hear from you! Apply today and let's build this together.
Please include:

• Your resume highlighting product management experience with AI/ML products or data-intensive B2B/SaaS platforms

• A brief description of an AI-powered feature or product you've shipped and its measurable impact

• Any experience with pharmaceutical, cold chain, life sciences, or logistics domains

• Your vision for how LLMs and agentic AI can transform enterprise supply chain operations

Originally posted on Himalayas