PK/PD首席科学家
PK/PD Principal Scientist
Zoetis 是动物健康领域的全球领导者，正在寻找一位充满热情的同事加入我们的兽医学研究与开发（VMRD）PK/PD 科学家团队，为兽医学开发新型治疗药物。成功候选人将主要负责设计、执行、分析和解释多种物种的体内 PK/PD 研究，以支持从早期研究到后期开发的项目。该职位需要一位高度积极、独立的领导者，能够与其他团队成员有效协作以推进项目。
职位职责：
- 独立设计并分析多种兽医物种的体内 PK/PD、PK 和 TK 研究，包括撰写研究方案和报告。
- 为选择先导化合物和优化给药方案提供 PK 和 PK/PD 模型与模拟支持。
- 与生物分析团队合作，评估分析方法的适用性，并预测项目的分析需求。
- 在治疗领域内领导科学策略的制定，重点关注机制平台/生物标志物，以促进转化、靶点结合的测量和给药方案预测。
- 与多学科团队协作并有效沟通，根据项目的战略方向设计和执行研究。
- 向科学团队、管理层和监管机构汇报研究成果。
- 撰写监管提交文件的部分内容，回应监管机构的查询，并保持对监管指南文件的了解。
所需教育背景和经验：
- 药理学、生物化学或相关领域的博士学历，具有 4 年以上相关制药开发经验。拥有 DVM DACVCP 或 DVM Dipl. ECVPT 资格者优先考虑。
- 具备设计、分析和解释体内 PK 和 PK/PD 研究的实际能力。有生物治疗药物（蛋白治疗药物）经验者优先考虑。
- 熟练使用 PK 和 PK/PD 分析软件，如 WinNonlin、Monolix 或 Watson。
- 必须具备优秀的口头和书面沟通能力。
- 自主性强，能够合理安排工作优先级，在最少监督下高效工作。
- 了解生物分析方法。
- 了解 ADA 检测和生物治疗药物免疫原性的评估者优先考虑。
- 具有 PK/PD 模型与模拟经验，如使用 NONMEM、R 或其他工具进行 PBPK、QSP 或群体 PK 模型。
查看英文原文
Zoetis, a global leader in animal health, seeks an enthusiastic colleague to join our Veterinary Medicine Research and Development (VMRD) PK/PD Scientist Team to discover and develop novel therapeutics for veterinary medicine. The successful candidate will be primarily responsible for designing, conducting, analyzing, and interpreting in vivo PK/PD studies in multiple species in support of projects from early research through late-stage development. This position will require a highly motivated and independent leader who can effectively collaborate with other team members to advance projects.
POSITION RESPONSIBILITIES:
- Independently design and analyze in vivo PK/PD, PK and TK studies in multiple veterinary species, including writing study protocols and reports.
- Provide PK and PK/PD modeling and simulation to help select lead candidates and optimize dose regimens.
- Collaborate with bioanalytical team to assess suitability of analytical assays and forecast analytical requirements for projects.
- Lead development of scientific strategy across therapeutic areas with a focus on mechanistic platforms/biomarkers to aid in translation, measurement of target engagement, and dose regimen predictions.
- Work collaboratively and communicate effectively with multidisciplinary teams to design and prosecute studies in line with the strategic direction of the project.
- Present research results to scientific teams, management, and regulatory agencies.
- Write sections of regulatory submissions, respond to inquiries from regulatory agencies, and maintain knowledge of regulatory guidance documents.
REQUIRED EDUCATION AND EXPERIENCE:
- Ph.D in pharmacology, biochemistry, or related field with 4 or more years of relevant pharmaceutical development experience. DVM DACVCP or DVM Dipl. ECVPT is highly desirable.
- Proven ability to design, analyze and interpret in vivo PK and PK/PD studies.Experience with biotherapeutics (protein therapeutics) is highly desirable.
- Skilled in the use of PK and PK/PD analysis software such as WinNonlin, Monolix or Watson.
- Must have excellent verbal & written communication skills.
- Self-starter, able to prioritize work and work efficiently with minimal supervision.
- Working knowledge of bioanalytical methodology.
- Knowledge of ADA assays and assessment of immunogenicity of biotherapeutics is highly desirable.
- Experience in PK/PD modeling and simulation such as PBPK, QSP or population PK modeling using NONMEM, R, or related software is highly desirable.
- Experience interacting with regulatory agencies is highly desirable.
- Experience conducting GLP studies is desirable.
The US base salary range for this full-time position is $114,000 - $185,000. Our salary ranges are determined by role, level, and location. The range displayed on each job posting reflects the base pay target range for new hire salaries for the position. Within the range, individual pay is determined by work location and additional factors, including job-related skills, experience, and relevant education or training.
This position is also eligible for short-term incentive compensation
This position is also eligible for long-term incentives
In addition to compensation, Zoetis offers a comprehensive benefits package that supports the physical, emotional and financial wellbeing of our colleagues and their families including healthcare and insurance benefits beginning
on day one, a 401K plan with a match and profit-sharing contribution from Zoetis, and 4 weeks of vacation.
Visit to learn more.
Full timeRegularColleagueAny unsolicited resumes sent to Zoetis from a third party, such as an Agency recruiter, including unsolicited resumes sent to a Zoetis mailing address, fax machine or email address, directly to Zoetis employees, or to Zoetis resume database will be considered Zoetis property. Zoetis will NOT pay a fee for any placement resulting from the receipt of an unsolicited resume.
Zoetis will consider any candidate for whom an Agency has submitted an unsolicited resume to have been referred by the Agency free of any charges or fees. This includes any Agency that is an approved/engaged vendor but does not have the appropriate approvals to be engaged on a search.
Notice: Zoetis Recruiters will contact candidates via email from an address ending in @zoetis.com and may also initially connect with candidates through LinkedIn, including LinkedIn InMail. Zoetis does not use Gmail, Outlook, Yahoo, or other web-based/generic email domains to communicate about job opportunities, interviews, or offers of employment. If you receive a recruitment-related email message claiming to be from Zoetis that does not come from @zoetis.com, please treat it as suspicious. For your security, do not reply, click links, open attachments, share personal or financial information, or send money in response to unexpected or questionable recruitment communications.
Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of “@zoetis.com”. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.Originally posted on Himalayas