毕业生实习 — 小分子计算安全建模
Grad Co-op — Computational Safety Modeling for Small Molecules
### **职业类别**
应届生岗位
### **职位描述**
### 加入安进，为患者服务
在安进，如果你觉得自己是更大事业的一部分，那确实如此。我们的共同使命——为患有严重疾病的患者服务——推动着我们所做的一切。
自1980年以来，我们在对抗世界上最难治愈的疾病方面，帮助开创了生物技术的世界。我们专注于四个治疗领域——肿瘤学、炎症、普通医学和罕见病，每年影响数百万患者。安进正在推进广泛的药物管线，用于治疗癌症、心脏病、炎症性疾病、罕见病以及肥胖及其相关疾病。作为安进团队的一员，你将帮助对患者的生活产生持久的影响，我们通过研究、生产和交付创新药物，帮助人们活得更长、更充实、更快乐。
我们获奖的文化具有协作性、创新性和基于科学的特点。如果你热衷于挑战，并且能从其中找到机会，你将在安进团队中茁壮成长。加入我们，改变患者的生命，同时改变你的职业生涯。
**研究生实习 —— 小分子计算安全建模**
### 你将负责的工作
让我们一起行动，改变世界。我们正在寻找一名研究生实习人员，帮助扩展我们用于评估小分子药物候选物安全性及其他潜在疗法的计算工具。与计算科学家和非临床安全专家合作，你将参与制定一种策略，在药物发现早期提供有用的预测，并在实验数据可用时将其纳入评估中。
这个职位结合了科学数据评估、模型开发以及与使用安全信息指导化合物设计和测试的研究人员的合作。具体的毒性终点将由团队根据科学需求和可用数据的质量来选择。
**你将负责的工作**
- 识别、整理并比较相关外部和内部数据，包括化学结构、实验结果和暴露信息（如有的话）
- 开发并评估适合每个问题的方法。这些可能包括结构警报、基于类似物的读取交叉、机器学习，以及整合实验结果与其他安全证据的模型
- 在与预期用途相关的化合物上评估性能，并记录使用背景
查看英文原文
### **Career Category**
College Job
### **Job Description**
### Join Amgen’s Mission of Serving Patients
At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.
Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
**Grad Co-op — Computational Safety Modeling for Small Molecules**
### What You Will Do
Let’s do this. Let’s change the world. We are seeking a graduate co-op to help expand our computational toolbox for assessing the safety of small molecule drug candidates and potentially other modalities. Working with computational scientists and nonclinical safety experts, you will contribute to a strategy that provides useful predictions early in drug discovery and brings experimental evidence into the assessment as it becomes available.
This role combines scientific data assessment, model development, and collaboration with the researchers who use safety information to guide compound design and testing. The specific toxicity endpoints will be selected with the team based on scientific need and the quality of available data.
**What you will do**
- Identify, curate, and compare relevant external and internal data, including chemical structures, assay results, and exposure information where available
- Develop and evaluate approaches suited to each question. These may include structural alerts, analogue-based read-across, machine learning, and models that integrate experimental results with other safety evidence
- Evaluate performance on compounds relevant to the intended use, and document context of use, uncertainty, applicability, and important limitations
- Work with computational scientists, medicinal chemists, and toxicologists to explore how model outputs can guide compound prioritization and follow-up experiments
- Present results and deliver reproducible analyses, documented model prototypes, and recommendations for further development
- Provide mechanisms for retraining as additional data is generated over time
### Program Eligibility Requirements
- Must be available to work a part-time schedule.
- Expected continued enrollment in an accredited college or university following the internship program / co-op
- Student must be located in the United States for the duration of the internship program
### What We Expect of You
We are all different, yet we all use our unique contributions to serve patients. The individual we seek is a team player with these qualifications:
**Basic Qualifications:**
Amgen requires that all individuals applying for a grad internship or a co-op assignment at Amgen must meet the following criteria:
- 18 years or older
- Graduated with a bachelor’s degree from an accredited college or university
- Currently enrolled in an MBA program for an MBA internship OR a Master’s program for a Master’s internship OR a PharmD program for a PharmD internship OR Ph.D. for a PhD internship from an accredited college or university and completion of the first year of MBA OR Master’s OR Pharm D OR Ph.D. program before the internship starts
**Preferred Qualifications:**
- Currently pursuing a graduate degree in cheminformatics, bioinformatics, computational chemistry or biology, data science, statistics, toxicology, or a related field
- Experience using Python to analyze scientific data
- Familiarity with statistical modeling and machine learning including the principles of model evaluation
- Ability to communicate technical findings clearly and work with scientists from different disciplines
- Experience with cheminformatics, predictive toxicology, or analysis of in vitro assay data
- Familiarity with small molecule drug discovery or nonclinical safety assessment
- Experience combining data from multiple sources and documenting reproducible computational workflows
- Familiarity with version control and collaborative software development
### What You Can Expect of Us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.
The base pay range for this opportunity in the U.S. is $35.34 - $41.20 per hour.
- Build a network of colleagues that will endure and grow throughout your time with us and beyond.
- Bring your authentic self to the table and become the professional you’re inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.
- Participate in executive and social networking events, as well as community volunteer projects.
### **Apply now and make a lasting impact with the Amgen team.**
### **careers.amgen.com -** Please search for Keyword R-257124
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
### Application deadline
Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.
### Sponsorship
Candidates must be authorized to work in the U.S. for the duration of this program. Sponsorship for future FTE roles is not guaranteed.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
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**Salary Range**
USD - USD