高级科学家，外部能力
Associate Principal Scientist, External Capabilities
职位描述
高级科学研究员向小分子工艺研发部的外部能力团队汇报。
成功候选人将负责为我们在外部合作伙伴处的科学家团队提供科学领导和监督。该职位在合成路线设计、路线筛选、工艺优化与开发，以及活性药物成分（API）的交付方面，提供定期的科学指导和及时的问题解决，以支持公司的小分子产品管线。
该职位需要与工艺化学、发现工艺化学、赋能技术、化工工程研发、分析研发、质量以及其他合作伙伴团队有效协作，以开发创新且实用的合成化学和工艺开发解决方案。该人员需跨内部和外部团队工作，以确保在紧张的项目时间表下成功交付API。
该职位要求具备扎实的有机合成化学专业知识和广泛的药品开发知识。任职者需运用良好的科学判断力，识别并管理技术风险，并通过数据驱动的建议和有效的解决问题来影响项目团队。
作为小分子工艺研发部内的科学贡献者和项目负责人，该职位期望建立广泛的内部网络，从技术和战略角度对一系列项目做出贡献，并支持组织内同事的科学发展。该人员可能需要指导经验较少的科学家，并参与职能或跨职能的科学倡议。
高级科学研究员需与战略外部合作伙伴的科学家和管理层建立并维护良好的工作关系。该职位需在公司和合作伙伴团队中推广科学卓越、信任、协作、质量、安全和合规的文化。
强大的沟通、谈判、影响力和关系管理技能对于在不同地理区域和文化背景下建立有效合作至关重要。成功候选人必须能够清晰地传达技术期望，建设性地挑战科学提案，协调利益相关者，并推动外部团队实现高质量和及时的成果。
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Job Description
The Associate Principal Scientist reports into the External Capabilities group within Small Molecule Process Research & Development.
The successful candidate will be responsible for providing scientific leadership and oversight for teams of scientists at our external partners. The role provides regular scientific direction and timely problem-solving in the areas of synthetic route design, route scouting, process optimization and development, and active pharmaceutical ingredient, API, delivery in support of the Company’s small-molecule pipeline.
The incumbent collaborates effectively with Process Chemistry, Discovery Process Chemistry, Enabling Technologies, Chemical Engineering Research & Development, Analytical Research & Development, Quality, and other partner groups to develop innovative and practical solutions to synthetic chemistry and process-development challenges. The individual will work across internal and external teams to help ensure successful API deliveries under demanding project timelines.
The position requires strong subject-matter expertise in synthetic organic chemistry and broad knowledge of pharmaceutical development. The incumbent is expected to apply sound scientific judgment, identify and manage technical risks, and influence project teams through data-driven recommendations and effective problem-solving.
As a scientific contributor and project leader within Small Molecule Process Research & Development, the incumbent is expected to build a broad internal network, contribute technically and strategically across a portfolio of programs, and support the scientific development of colleagues within the organization. The individual may mentor less-experienced scientists and contribute to functional or cross-functional scientific initiatives.
The Associate Principal Scientist builds and maintains strong working relationships with scientists and management at strategic external partners. The incumbent promotes a culture of scientific excellence, trust, collaboration, quality, safety, and compliance across Company and partner teams.
Strong communication, negotiation, influencing, and relationship-management skills are essential for establishing effective partnerships across diverse geographies and cultures. The successful candidate must be able to communicate technical expectations clearly, constructively challenge scientific proposals, align stakeholders, and drive external teams toward high-quality and timely outcomes.
**Primary Responsibilities**
- Provide scientific leadership and day-to-day technical oversight for process chemistry activities conducted at external partners.
- Guide synthetic route design, route scouting, process optimization, reaction understanding, impurity-control strategy, process robustness, and preparation of intermediates and APIs.
- Serve as a key scientific interface between external partners and internal project teams, ensuring that technical priorities, deliverables, risks, and timelines are clearly understood.
- Critically evaluate experimental plans, data packages, development reports, and technical proposals from external partners.
- Identify emerging scientific, operational, quality, and delivery risks, and work with internal and external stakeholders to establish practical mitigation plans.
- Apply innovative and rigorous problem-solving approaches to complex synthetic chemistry and process-development challenges.
- Collaborate with Process Chemistry, Discovery Process Chemistry, Enabling Technologies, Chemical Engineering Research & Development, Analytical Research & Development, Quality, and other partner functions to advance programs and support successful API delivery.
- Contribute to technical and strategic decisions for assigned projects or a portfolio of programs through clear, data-based recommendations.
- Establish productive relationships with scientists and management at external partner organizations and promote transparent communication and timely issue escalation.
- Support effective knowledge transfer between external partners and internal project teams.
- Promote high standards of scientific rigor, documentation, quality, data integrity, safety, and compliance across external activities.
- Contribute to the development and implementation of external capability strategies, working practices, scientific standards, and continuous-improvement initiatives.
- Mentor and support the scientific development of colleagues and external-partner scientists, as appropriate.
- Communicate project progress, technical risks, key decisions, and recommended actions clearly to scientific and cross-functional stakeholders.
**Qualifications**
**Education Requirement**
- Ph.D. in synthetic organic chemistry or a closely related field.
**Required Experience and Skills**
- Relevant pharmaceutical or biotechnology industry experience in synthetic chemistry, process chemistry, or closely related drug-development activities.
- Demonstrated ability to independently lead complex scientific activities and effectively guide multidisciplinary or external project teams.
- Strong knowledge of synthetic organic chemistry, route design, process development, reaction optimization, impurity control, and scale-up considerations.
- Demonstrated record of delivering high-quality scientific results through innovation, sound judgment, and proactive problem-solving.
- Ability to critically analyze complex experimental data, identify technical risks, and recommend practical development strategies.
- Experience collaborating across scientific and operational functions to achieve project objectives and delivery commitments.
- Strong interpersonal, written, and verbal communication skills.
- Effective negotiation, influencing, collaboration, and relationship-management skills.
- Ability to work effectively across organizational boundaries, cultures, geographies, and time zones.
- Demonstrated commitment to scientific excellence, data integrity, quality, safety, compliance, and ethical decision-making.
- Evidence of scientific contribution through publications, presentations, patents, internal technical reports, process-development accomplishments, or other relevant forms of scientific impact.
- Ability and willingness to travel approximately **25% of the time**, based on business needs.
**Preferred Experience**
- Experience providing scientific oversight for work performed at contract development and manufacturing organizations or other external research and development partners.
- Experience with synthetic route development and process scale-up from laboratory studies through multikilogram or manufacturing-scale execution.
- Experience supporting API deliveries across one or more stages of pharmaceutical development.
- Familiarity with technology transfer, external manufacturing, analytical control strategies, process safety, quality systems, and regulatory expectations relevant to pharmaceutical development.
- Experience working on multiple projects or programs with competing technical priorities and timelines.
- Experience mentoring scientists or providing technical guidance to project teams.
- Demonstrated ability to establish effective working relationships with external scientists, project leaders, and partner-site management.
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
**Required Skills:**
Analytical Chemistry, Chemical Synthesis, Chemistry, Clinical Judgment, Contract Research Organizations (CROs), Cross-Cultural Awareness, Data Analysis, Next Generation Science Standards, Organic Chemistry, Research Development, Researching, Scientific Analysis, Scientific Presentations, Scientific Research, Scientific Reviews, Small Molecules, Synthetic Chemistry
**Preferred Skills:**
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**Employee Status:**
Regular
**Relocation:**
**VISA Sponsorship:**
**Travel Requirements:**
**Flexible Work Arrangements:**
Remote
**Shift:**
**Valid Driving License:**
**Hazardous Material(s):**
**Job Posting End Date:**
09/24/2026
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